CoFe2O4@SiO2-PA-CC-Guanidine MNPs as an Efficient Catalyst for the One-Pot, Four-Component Synthesis of Pyrazolopyranopyrimidines

摘要

A new and mild protocol for the synthesis of pyrazolopyrano- pyrimidines using CoFe2O4@SiO2-PA-CC-Guanidine MNPs in water at room temperature was reported. Pyrazolopyranopyr- imidine derivatives were synthesized from reaction between hydrazine hydrate, ethylacetoacetate, aldehydes and barbituric acid derivatives in good to excellent yields. This nanocatalyst was characterized by FT-IR spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Thermogravimetric analysis (TGA) and vibrating sample magnetometry (VSM) techniques. CoFe2O4@SiO2-PA-CC-Guanidine MNPs have high activity and easy separation from the reaction mixture. This magnetic nanocatalyst has recovery capability and can be reused for the several times.