Binary and Ternary Zinc(II) Complexes of Acyl Pyrazolones: Synthesis, Spectroscopic Analysis, Crystal Structure and Antimalarial Activity

摘要

A new series of ZnII metal complexes of ligands 4-(4- chlorobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3- one (PCBPMP) and 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4- dihydro-3H-pyrazol-3-one (PCBTPMP) were prepared and char- acterized. The nature of bonding and the stereochemistry of the complexes were deduced from 1 H and 13 C Nuclear Magnetic Resonance (NMR), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), Molar conductivity measurements and Single-crystal X-ray diffraction. The analyses indicated that complexes 1, 2 and 3 are mononuclear and exhibited octahedral geometry around ZnII . The potential in silico and in vitro antimalarial activity inhibits Plasmodium falciparum and the same was exhibited by Ligands and Zinc complexes. This would be the first report of the antimalarial activity of Zinc complexes of acyl pyrazolones ligand.