Synthesis of β3 -Aryl-Alaninyl Derivatives by sp3 C-H Activation with Pd(OAc)2 Catalyst/Pivalic Acid in DCE and Their Structural Studies in Solid State

摘要

Aryl-β-amino acid derivatives are structural constituents of various bioactive natural products, and their peptides have unique folding features for the formation of secondary structure. The substituted β3-amino acids are mostly prepared from α-amino acid by Arndt-Eistert homologation of α-amino acids, conjugate addition and Mannich reactions synthetic methods.