Syntheses of 4-OH and 5-OH Imidacloprids

摘要

4-OH and 5-OH imidacloprids, important metabolites of neonicotinoid insecticides, were synthesised in 4 steps starting from S-methylisothiourea sulfate. The structure of 4-OH imidacloprid was determined by X-ray crystallographic analysis. This is the first example of the synthesis of both metabolites independently.