Access to Polyfluorinated Tetrahydropyranyl Amides via Prins-Ritter Cyclization under Green Conditions

摘要

The formation of 4-amido-substituted tetrahydropyrans by Prins-Ritter cyclisation under green solvent-free conditions was investigated.The optimal conditions were applied to the synthesis of different tetrahydropyranyl amides,and subsequently to a new family of polyfluorinated derivatives when starting from hepta-1,6-dien-4-ol.