Asymmetric catalytic carbon-carbon coupling reactions via C-H bond activation

摘要

Asymmetric catalytic C-C coupling reactions via C-H bond activation are currently among the most attractive and powerful tools in synthetic organic chemistry. In the past few decades, a variety of catalytic asymmetric C-C coupling reactions via C-H bond activation have been reported. Compared with traditional asymmetric C-C bond formation reactions, C-H activation/ C-C coupling strategies have more advantages in terms of power and cost-effectiveness. In this review, after a short introduction of C-H activation/C-C coupling reactions, recent studies on C-H activation/C-C coupling reactions are reviewed, with an emphasis on enantioselective cross-dehydrogenative-coupling, C-H activation/olefin coupling reactions, hydroacylation of aldehydes via C-H activation, as well as C-H activation/R-X(M) coupling reactions.