Intranasal administration of retinyl palmitate with a respiratory virus vaccinecorrects impaired mucosal IgA response in the vitamin A-deficient host.

摘要

Our previous studies showed that intranasal vaccination of vitamin A-deficient(VAD) mice failed to induce normal levels of upper respiratory tract IgA, a firstline of defense against respiratory virus infection. Here we demonstrate that theimpaired responses in VAD animals are corrected by a single intranasalapplication of retinyl palmitate with the vaccine. Results encourage the clinicaltesting of intranasal vitamin A supplements to improve protection againstrespiratory viral disease in VAD populations.