Pd(II)-Catalyzed Chelation-Induced C(sp~2)-H Acylation of(Hetero)Arenes Using Toluenes as Aroyl Surrogate

摘要

In the last few years,transition-metal-catalyzed chelationcontrolled ortho-acylation utilizing methyl arene as the acyl partner has emerged as a powerful technique to achieve diverse complexity with diaryl ketone skeleton contrast to the traditional cross-coupling/Friedel-Craft reaction.Diaryl ketones are a significant building block that exists in pharmaceuticals,agrochemicals,natural products,functional materials,and many other useful compounds.In this context,the up-to-date developments in Pd(II)-catalyzed ortho-acylations of arenes and heteroarenes with toluenes as acyl surrogate are studied with advantages,limitations,mechanistic pathways,and prospective.