Cu/Pd-Catalyzed One-Pot Synthesis of 2-(1,2,3-Triazolyl) methyl-3-alkynylImidazo[1,2-a]pyridines Involving Sequential SN Reaction/[3+2] Cycloaddition/Sonogashira Coupling Reactions

摘要

An efficient one-pot regioselective synthesis of 2-(1,2,3-triazol- yl)methyl-3-alkynyl imidazo[1,2-a]pyridines is reported under simple and mild reaction conditions. The new imidazo[1,2-a] pyridines embedded with 4-substituted-[1,2,3]-triazole were obtained in good to excellent yields from 2-(chloromethyl)-3- iodo imidazo[1,2-a]pyridines via a one-pot sequence involving an SN reaction with azide, followed by copper-catalyzed [3+2] cycloaddition and a Sonogashira coupling reaction.