[1,2]-Shift in Chiral Ni(II) Schiff-Base Derivatives: Conversion of α- Thiobenzylated Amino Acid into the Cysteine Derivative

摘要

The first example of the anionic [1,2]-shift taking place in the metal coordination environment is described. The α-thiobenzy- lated glycine in the form of the Ni(II) Schiff-base complex is converted into the corresponding cysteine derivative with ca 70% yield. The reaction disclosed emphasizes how the reactivity of a substrate can be influenced by noncovalent interactions in the metal coordination environment.