Facile Synthesis of Amides through Transamidation with Iodine under Neat Conditions

摘要

Iodine and NH2OH.HCl mediated transamidation of unactivated amides with a variety of amines under thermal/microwave irradiations.The current strategy is effective for a wide variety of primary,secondary,and tertiary amides and allows formylation,acylation,and benzoylation of various amines.The primary advantages of the current protocol are simple,rapid,absence of metal catalyst,low-cost starting material as a solvent,and low environmental impact during the synthesis process.