Zn Mediated Urea Bond Formation: A Novel and Convenient Method

摘要

The present work provides a fast and mild method towards the synthesis of urea derivatives and their application in amino group protection. This new methodology is an inexpensive, simple, and environmentally safe process for the synthesis of urea derivatives. It is well suited for aliphatic amines and aromatic amines. With aliphatic amines, Zn-mediated urea bond formation occurs at ambient temperature, whereas with aromatic amines, it occurs at 60 °C. Environmentally friendly reaction conditions, sustainability, enumerating tolerance of a wide variety of functional groups, cost-effectiveness, high atom economy, fast reaction time, and adaptability for large-scale synthesis are all benefits of this technology.