A Greener Approach to Oxazolidinone Synthesis Using a Ternary Deep Eutectic Solvent

摘要

By employing a ternary and environmentally benign deep eutectic solvent comprising choline chloride, glycerol, and aluminum chloride hexahydrate(ChCl/Glycerol/AlCl3.6H2O) as the catalyst and reaction media, three component reaction of epoxides, amines and dimethyl carbonate has been accomplished, which allows for the efficient construction of various 3,5-disubstituted oxazolidinones, important scaffolds in small molecule drug discovery. Simple reaction conditions and the use of green and sustainable materials and reagents make this a straightforward and practical methodology for obtaining various oxazolidinones.