Enantioselective Organocatalytic Michael Addition Reactions Catalyzed by Proline/Prolinol/Supported Proline based Organocatalysts:An Overview

摘要

Ever since the discovery of enantioselective organocatalytic Michael addition reactions,it has emerged as a significant path for synthesizing a variety of stereochemical products under mild conditions,also a prominent C X(X=C,O,N,S)bond formation reaction in organic chemistry.Over time,substantial progress has been accomplished in diversity-and targetoriented asymmetric Michael addition reactions.This review provides a brief overview of the results,scope,and limitations of several influential strategies involving enantio-selective Michael addition reactions promoted by mono-functional proline/prolinol/supported-proline-based chiral organocatalysts.Furthermore,we also sincerely believe that the various synthetic strategies documented in this review will pave a pathway to improve the status of Michael addition reactions for synthesizing various drug molecules involving complex intermediates.