Social differences in insulin-like growth factor-1: findings from a British birth cohort.

摘要

PURPOSE: Insulin-like growth factor-1 (IGF-1) is related to factors that are socially patterned and may play a role in social differences in the development of morbidities including disability. Our aim is to examine whether there are social differences in IGF-1 in a cohort of participants between 44 and 45 years of age. METHODS: We examine the association of IGF-1 with social position measured by father's or own occupational class at three time points in childhood and adulthood, in a cohort of individuals born in one month in 1958 (N = 3,374 men and 3,302 women). RESULTS: Lower IGF-1 levels were associated with lower social position measured with father's occupational class at birth (p < 0.0001) and own occupational class aged 42 years (p < 0.001). Adult social position was associated with IGF-1 independently of social position at birth (p < 0.001) or any covariates examined. CONCLUSIONS: IGF-1 secretion is associated with social position such that low social position is associated with lower levels ofIGF-1. This biomarker may play a role in the development of social differences in morbidities associated with aging, such as the development of disability.