Palladium-Catalyzed beta-C(sp(3))-H Arylation of Aliphatic Ketones Enabled by a Transient Directing Group

摘要

The direct arylation of aliphatic ketones has been developed via Pd-catalyzed beta-C(sp(3))-H bond functionalization with 2-(aminooxy)-N,N-dimethylacetamide as a novel transient directing group (TDG), which showed remarkable directing ability to generate arylated products in moderate to good yields. Furthermore, the reaction can tolerate abundant substrate of ketones and aryl iodides. This study expands the scope of applications for TDGs.