Vismodegib Efficacy in Advanced Basal Cell Carcinoma Maintained with 8-Week Dose Interruptions: A Model-Based Evaluation

Chanu Pascal; Musib Luna; Wang Xin; Cheeti Sravanthi; Girish Sandhya; Bruno Rene; Lu Tong; Reddy Josina; Jin Jin Y.; Caro Ivor

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Vismodegib Efficacy in Advanced Basal Cell Carcinoma Maintained with 8-Week Dose Interruptions: A Model-Based Evaluation

机译：Vismodegib在先进的基底细胞癌中的疗效保持8周的剂量中断：基于模型的评估

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来源
《The Journal of investigative dermatology.》 |2021年第4期|共5页
作者
Chanu Pascal; Musib Luna; Wang Xin; Cheeti Sravanthi; Girish Sandhya; Bruno Rene; Lu Tong; Reddy Josina; Jin Jin Y.; Caro Ivor;
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作者单位

Genentech Roche Dept Clin Pharmacol Lyon France;

Genentech Inc Dept Clin Pharmacol San Francisco CA 94080 USA;

Genentech Inc Dept Clin Pharmacol San Francisco CA 94080 USA;

Genentech Inc Dept Clin Pharmacol San Francisco CA 94080 USA;

Genentech Inc Dept Clin Pharmacol San Francisco CA 94080 USA;

Genentech Roche Dept Clin Pharmacol Marseille France;

Genentech Inc Dept Clin Pharmacol San Francisco CA 94080 USA;

Genentech Roche Prod Dev Oncol San Francisco CA USA;

Genentech Inc Dept Clin Pharmacol San Francisco CA 94080 USA;

Genentech Roche Prod Dev Oncol San Francisco CA USA;

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原文格式 PDF
正文语种 eng
中图分类皮肤病学与性病学;
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2. Cyclophosphamide, fluorouracil and low-dose interleukin-2 and salvage combination chemotherapy in advanced cutaneous squamous cell carcinoma [J] . Giovanni Lo Re, Paolo Doretto, Francesco Lo Re, 癌症转移与治疗（英文版） . 2020,第006期
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4. Low-Dose Vismodegib as Maintenance Therapy After Locally Advanced Basal Cell Carcinoma Complete Remission: High Efficacy with Minimal Toxicity [J] . Massimiliano Scalvenzi, Milena Cappello, Claudia Costa, Dermatology and Therapy . 2020,第3期

机译：低剂量Vismodegib作为局部高级基底细胞癌后的维护治疗方法完全缓解：高疗效与毒性最小
5. Open-label, randomized multicentre phase II study to assess the efficacy and tolerability of sunitinib by dose administration regimen (dose modification or dose interruptions) in patients with advanced or metastatic renal cell carcinoma: study protocol of the SURF trial [J] . Guillaume Mouillet, Marie-Justine Paillard, Tristan Maurina, Trials . 2018,第1期

机译：开放标签，随机，多中心II期研究，通过剂量给药方案（剂量修改或剂量中断）评估舒尼替尼在晚期或转移性肾细胞癌患者中的疗效和耐受性：SURF试验的研究方案
6. Managing adverse effects by dose reduction during routine treatment of locally advanced basal cell carcinoma with the hedgehog inhibitor vismodegib: a single centre experience [J] . Woltsche N., Pichler N., Wolf I., Journal of the European Academy of Dermatology and Venereology: JEADV . 2019,第4期

机译：通过刺猬抑制剂VISMODEGIB对局部晚期基础细胞癌的常规治疗过程中减少不良影响：单一中心经验
7. Efficacy of low-dose mTHPC-PDT for the treatment of basal cell carcinomas [C] . Christian S. Betz, Winrich Rauschning, Evgueni P. Stranadko, World congress of the International Photodynamic Association . 2009

机译：小剂量mTHPC-PDT治疗基底细胞癌的疗效
8. Evaluation of radiation response to different dose rates, with/without mild hyperthermia, in human breast carcinoma cell lines of different radiosensitivities [D] . Niedbala, Malgorzata 2004

机译：在不同放射敏感性的人乳腺癌细胞系中评估有/无轻度热疗时不同剂量率的放射反应
9. Low-Dose Vismodegib as Maintenance Therapy After Locally Advanced Basal Cell Carcinoma Complete Remission: High Efficacy with Minimal Toxicity [O] . Massimiliano Scalvenzi, Milena Cappello, Claudia Costa, 2020

机译：低剂量Vismodegib作为局部晚期基底细胞癌完全缓解后的维持疗法：具有最小毒性的高疗效
10. 432P Efficacy and tolerability of vismodegib treatment in locally advanced and metastatic basal cell carcinoma [O] . M. Gürbüz, I. Dogan, G. Utkan, 2020

机译：在局部先进和转移基底细胞癌中vismodegib治疗的432p疗效和耐受性
11. Basal Cell Carcinomas and Basal Cell Carcinoma-like Changes Overlying Dermatofibromas. [R] . Goette, D. K., Helwig, E. B. 1974

机译：基底细胞癌和基底细胞癌样变化覆盖皮肤纤维瘤。

Vismodegib Efficacy in Advanced Basal Cell Carcinoma Maintained with 8-Week Dose Interruptions: A Model-Based Evaluation

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