UGT2B17 as a disease accelerator in CLL

摘要

CLL is characterized by accumulation of malignant B cells in the blood, bone marrow, and lymphoid tissues and it has a very heterogeneous outcome.2 Multiple prognostic factors have been identified in CLL that predict poor outcome with the biggest drivers being immunoglobulin heavy chain (IgVn) unmutated status, ZAP-70 protein overex-pression, and the presence of select genomic abnormalities [del(17pl3.1) and del(11q22.3) or mutations {N0TCH1, SF3B1, and p53)]. Here, Gruber and colleagues identify for the first time that uridine diphospho (UDP) glucuronosyltransferase 2B17 (UGT2B17) is both overexpressed in CLL tumor cells and that high levels of UGT2B17mRNA correlate with shorter treatment-free survival and overall survival (see figure).