The estimated glomerular filtration rate as a test for chronic kidney disease: problems and solutions.

摘要

At the American Society of Nephrol-ogy Renal Week 2010, one of the authors (A.D.R.) presented the following question at an In-Depth Nephrology Course on Geriatric Nephrology:A 65-year-old woman donated a kidney to her son. Before donation, her serum cre-atinine level was 1.0 mg/dL, her estimated glomerular filtration rate (GFR) was 56 mL/ min/1.73 m~2, and her measured GFR was 82 mL/min/1.73 m~2, which was below the 2.5th percentile for 20-year-old potential kidney donors. The patient had no albuminuria or hypertension and was otherwise healthy. The kidney was biopsied during the transplant surgery. The biopsy revealed 2 of 20 glomeruli as globally sclerosed, a focus of tubular atrophy, and mild arteriosclerosis (findings present in less than 2.5% of 20-year-old donors).