A translational link between Fe and Epo.

摘要

Earlier this year, 2 papers in Cell Metabolism reported studies supporting a central role of the IRP1-HIF-2alpha axis in coordinating iron metabolism and oxygen sensing. Altogether, these 3 papers establish a molecular link between cellular iron status and erythropoietin production. Most of body iron is found in circulating red cells as an essential component of hemoglobin, and most of internal iron exchange cycles through the erythron. A strict coordination of oxygen sensing, erythropoiesis, and iron metabolism is indispensable, and this regulation has been finely tuned during evolution.