Controversy Swirls Around Early Goal-Directed Therapy in Sepsis: Pioneer Defends Ground-Breaking Approach to Deadly Disease

摘要

Plans to re-examine a research finding via a much larger set of clinical trials, a common event in medical research, have provoked an uncommon result: an unusually public airing in the mainstream media of allegations, financial questions and wounded professional pride.The research finding at the center of the dispute is early goal-directed therapy for sepsis, formulated 7 years ago1 by Emanuel P. Rivers, , , vice chairman and director of research in emergency medicine at Henry Ford Hospital in Detroit, MI. Dr. Rivers, who trained in critical care, emergency and internal medicine, proposed applying the "golden hour" to severe sepsis and septic shock.