The platelet Fc receptor: a new role for an old actor.

摘要

Garcia-Ojeda et al have carefully structured their case to circumvent these problems.1 They have dissected the effects of Gata3 deletion by using highly defined precursor cell populations, efficient and quantitative precursor frequency assays, gene expression monitoring and T-cell receptor gene rearrangement analyses, and temporally controlled excision of Gata3 in cells that have already reached a definitive T-lineage developmental stage. Their results extend our understanding of both the roles of GATA-3 in T-cell developmental progression and the specific dependence of T-cell precursors on GATA-3 for B-lineage fate exclusion.