The sequence of events in diffuse large B-cell lymphoma.

摘要

DLBCL is a heterogeneous disease with subtypes defined by distinct molecular signatures and clinical outcomes. Recent studies using massively parallel sequencing have demonstrated that DLBCL molecular subtypes also harbor distinct repertoires of somatic copy number alterations and single nucleotide variants (SNVs). These studies also highlighted alterations in distinct molecular pathways implicated in disease pathogenesis, including the role of histone modifications in the germinal center B-cell (GCB) subtype and B-cell receptor and NF-kB signaling in the activated B-cell (ABC) type. Identification of such pathways opens new avenues for attack to treat more aggressive lymphomas and provides new insight into lymphoma pathogeneisis.