Exosomal miR-22-3p from human umbilical cord blood-derived mesenchymal stem cells protects against lipopolysaccharid-induced acute lung injury

Zheng Yuanfang; Liu Jiyuan; Chen Ping; Lin Lu; Luo Yinzhu; Ma Xiaoying; Lin Jincai; Shen Ying; Zhang Liyan

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Exosomal miR-22-3p from human umbilical cord blood-derived mesenchymal stem cells protects against lipopolysaccharid-induced acute lung injury

机译：来自人脐带血液衍生的间充质干细胞的外泌体miR-22-3p可保护脂多糖诱导的急性肺损伤

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摘要

Background: Mesenchymal stem cells (MSCs) are widely applied in various clinical disorders, including acute lung injury (ALI). We aimed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs)-derived exosomal microRNA-22-3p (miR-22-3p) on lipopolysaccharid (LPS)-induced ALI via regulating frizzled class receptor 6 (FZD6).

机译：背景：间充质干细胞（MSCs）广泛应用于各种临床疾病，包括急性肺损伤（ALI）。我们旨在研究人脐血来源的间充质干细胞（UCB-MSCs）来源的外体microRNA-22-3p（miR-22-3p）通过调节frizzled类受体6（FZD6）对脂多糖（LPS）诱导的ALI的影响。

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来源
《Life sciences》 |2021年第1期|共11页
作者
Zheng Yuanfang; Liu Jiyuan; Chen Ping; Lin Lu; Luo Yinzhu; Ma Xiaoying; Lin Jincai; Shen Ying; Zhang Liyan;
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作者单位

Fujian Med Univ Dept Neonatol Affiliated Fuzhou Children Hosp 145 Middle Rd 817 Fuzhou 350005;

Fujian Med Univ Dept Neonatol Affiliated Fuzhou Children Hosp 145 Middle Rd 817 Fuzhou 350005;

Fujian Med Univ Dept Neonatol Affiliated Fuzhou Children Hosp 145 Middle Rd 817 Fuzhou 350005;

Fujian Med Univ Dept Neonatol Affiliated Fuzhou Children Hosp 145 Middle Rd 817 Fuzhou 350005;

Fujian Med Univ Dept Neonatol Affiliated Fuzhou Children Hosp 145 Middle Rd 817 Fuzhou 350005;

Fujian Med Univ Dept Neonatol Affiliated Fuzhou Children Hosp 145 Middle Rd 817 Fuzhou 350005;

Fujian Med Univ Dept Neonatol Affiliated Fuzhou Children Hosp 145 Middle Rd 817 Fuzhou 350005;

Fujian Med Univ Dept Neonatol Affiliated Fuzhou Children Hosp 145 Middle Rd 817 Fuzhou 350005;

Fujian Med Univ Dept Neonatol Affiliated Fuzhou Children Hosp 145 Middle Rd 817 Fuzhou 350005;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Acute lung injury; Human umbilical cord blood-derived mesenchymal stem cells; Exosomes; MicroRNA-22-3p; Frizzled class receptor 6; Proliferation; Apoptosis;

机译：急性肺损伤;人脐血间充质干细胞;外质体;MicroRNA-22-3p;卷曲型6类受体;激增凋亡;

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2. Functional recovery and microenvironmental alterations in a rat model of spinal cord injury following human umbilical cord blood-derived mesenchymal stem cells transplantation [J] . Hongtao Zhang, Huilin Yang, Huanxiang Zhang2 中国神经再生研究：英文版 . 2010,第003期
3. Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181 [J] . Xintong Sui, Wei Liu, Zhi Liu 生物化学与生物物理学报：英文版 . 2021,第006期
4. Collagen scaffold combined with human umbilical cord-mesenchymal stem cells transplantation for acute complete spinal cord injury [J] . Wu-Sheng Deng, Sai Zhang, Ke Ma, 中国神经再生研究（英文版） . 2020,第009期
5. Effect of Chinese Materia Medica with Tonifying Kidney Function on Transplantation of Multipotency Mesenchymal Stem Cells from Human Umbilical Cord in Mice Model of Acute Kidney Injury [J] . Xiao-qian Chu1, Li Wang2, Wen Li1, 中草药：英文版 . 2016,第002期
6. Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice [J] . Eun Sun Kim, Yun Sil Chang, Soo Jin Choi, Respiratory Research . 2011,第1期

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Exosomal miR-22-3p from human umbilical cord blood-derived mesenchymal stem cells protects against lipopolysaccharid-induced acute lung injury

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