Natural IgM antibodies help fend off thrombosis

摘要

It is tempting to view the immune system as a thrombosis driver,(1) but the article by Obermayer et al(2) in this issue of Blood provides a counterpoise through the discovery of an anticoagulant role for innate immunity. Their article linking circulating microvesicles with natural immunoglobulin M (IgM) antibodies is an intriguing story with high clinical significance.