RHOG: Rac1-ing up another HLH gene

摘要

In this issue of Blood, Kalinichenko et al identify biallelic mutations in RHOG, the gene encoding the small GTPase RhoG, as a novel genetic cause of hemophagocytic lymphohistiocytosis (HLH). This study pinpoints RhoG as an important regulator of lymphocyte cytotoxicity and systematically deciphers the underlying mechanisms.