Anti-CD44 (Kur)lander hits ITP

摘要

In this issue of Blood, Norris et al describe the mechanism by which monoclonal antibodies to CD44 (anti-CD44) protect against antibody-mediated platelet destruction in murine immune thrombocytopenia (ITP). The antibodies inhibit phagocytosis by targeting the macrophage cell surface by binding to CD44 combined with Fc-dependent blockade of Fc gamma-receptors (Fc gamma Rs).