Two metal-organic frameworks for selective C2H2/CO2 separation and exert therapeutic effect on postpartum hemorrhage by increasing the prothrombin activity

摘要

In this research, two novel MOFs have been prepared through utilizing two similar organic tetracarboxylic ligands with different functional groups, and their chemical formulae are (H2NMe2)[(Gd (L-1)(H2O)2]center dot 2H(2)O (1, L-1 = [1,184',1 ''-terphenyl]-2,2 '',5,5 ''-tetracarboxylic acid) and [Gd-3(L-2)(2)(HCOO)(H2O)(4)]center dot 6H(2)O (2, L-2 = 2',5'-difluoro-[1,1':4',]''-terphenyl]-2,2 '',5,5 ''-tetracarboxylic acid). The gas sorption measurements reveal that complex 2 could selective adsorb C2H2 from a mixture of C2H2/CO2 around the ambient temperature. In order to generate novel candidates to conduct the treatment of postpartum hemorrhage, the prothrombin time (PT) and fibrinogen (FIB) determination was conducted after compounds treatment. The levels of inflammatory cytokines of TNF-alpha and IL-1 beta on postpartum hemorrhage animal model were evaluated with ELISA detection kit.