Cancer-associated fibroblasts are an infrequent finding in the microenvironment of proliferative verrucous leukoplakia-associated squamous cell carcinoma

Akrish Sharon J.; Rachmiel Adi; Sabo Edmond; Vered Marilena; Ben-Izhak Ofer

首页> 外文期刊>Journal of oral pathology and medicine: Official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology >Cancer-associated fibroblasts are an infrequent finding in the microenvironment of proliferative verrucous leukoplakia-associated squamous cell carcinoma

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Cancer-associated fibroblasts are an infrequent finding in the microenvironment of proliferative verrucous leukoplakia-associated squamous cell carcinoma

机译：癌症相关的成纤维细胞在增殖疣状白斑相关鳞状细胞癌的微环境中是一种不常见的发现

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BackgroundCancer-associated fibroblasts (CAFs) are generally associated with negative prognostic factors. This study compares the clinicopathologic impact of CAFs in oral squamous cell carcinoma in patients with a history of proliferative verrucous leukoplakia (p-scca) and patients with conventional squamous cell carcinoma of the buccal mucosa, gingiva, and palate (c-scca).

机译：背景癌症相关成纤维细胞（CAF）通常与负面预后因素相关。本研究比较了有增生性疣状白斑（p-scca）病史的患者和有颊粘膜、牙龈和腭部常规鳞状细胞癌（c-scca）患者口腔鳞状细胞癌中CAF的临床病理影响。

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《Journal of oral pathology and medicine: Official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology》 |2017年第5期|共6页
作者
Akrish Sharon J.; Rachmiel Adi; Sabo Edmond; Vered Marilena; Ben-Izhak Ofer;
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作者单位

Rambam Med Ctr Dept Oral &

Maxillofacial Surg Haifa Israel;

Rambam Med Ctr Dept Oral &

Maxillofacial Surg Haifa Israel;

Rambam Med Ctr Dept Pathol Haifa Israel;

Tel Aviv Univ Sch Dent Dept Oral Pathol &

Oral Med Tel Aviv Israel;

Rambam Med Ctr Dept Pathol Haifa Israel;

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原文格式 PDF
正文语种 eng
中图分类口腔科学;
关键词
alpha-smooth muscle actin; cancer-associated fibroblasts; microenvironment; oral squamous cell carcinoma; proliferative verrucous leukoplakia;

机译：α-平滑肌肌动蛋白;癌相关成纤维细胞;微环境;口腔鳞状细胞癌;增生性疣状白斑;

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3. Clinicopathologic analysis of verrucous hyperplasia, verrucous carcinoma and squamous cell carcinoma as part of the clinicopathologic spectrum of oral proliferative verrucous leukoplakia: A literature review and analysis [J] . Sharon Akrish, Lana Esker-Hashoul, Adi Rachmiel, Pathology Research and Practice . 2019,第12期

机译：疣状增生，疣状癌和鳞状细胞癌的临床病理分析，作为口服增殖性疣状的临床病理谱的一部分：文献综述和分析
4. Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma: Usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibroblast phenotype [J] . OnoS., IshiiG., NagaiK., Chest: The Journal of Circulation, Respiration and Related Systems . 2013,第4期

机译：Podoplanin阳性与癌症相关的成纤维细胞可能具有独立于I期肺鳞癌癌细胞表型的预后价值：结合癌细胞表型和癌症相关成纤维细胞表型的分析的有用性
5. Relationship between podoplanin-expressing cancer-associated fibroblasts and the immune microenvironment of early lung squamous cell carcinoma [J] . Suzuki Jun, Aokage Keiju, Neri Shinya, Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2021,第1期

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6. Cancer-associated fibroblast expression of serine protease fibroblast activation protein increases tumour metastatic potential and alters cell death mechanisms [C] . Baird S.K., Rentier C., Smyth F.E Incorporating of the Australian Society for Biochemistry and Molecular Biology Combio . 2009

机译：丝氨酸蛋白酶成纤维细胞活化蛋白的癌症相关的成纤维细胞表达增加了肿瘤转移性潜力和改变细胞死亡机制
7. Cancer Associated Fibroblasts Promote the Invasion of Head and Neck Squamous Cell Carcinoma in TRACER Cultures [D] . Dean, Teresa. 2018

机译：癌症相关的成纤维细胞促进TRACER培养中头颈部鳞状细胞癌的侵袭
8. PLAU directs conversion of fibroblasts to inflammatory cancer-associated fibroblasts promoting esophageal squamous cell carcinoma progression via uPAR/Akt/NF-κB/IL8 pathway [O] . Lingling Fang, Yun Che, Chaoqi Zhang, 2021

机译：奉献指示成纤维细胞转化为炎症癌症相关的成纤维细胞通过UPAR / AKT / NF-κB/ IL8途径促进食管鳞状细胞癌进展
9. Verrucous carcinoma of the female breast:Verrucous carcinoma is a rare skin malignancy of squamous cell origin. It is characterised by negligible cellular atypia and a low mitotic rate. These are reflected in slow locally invasive behaviour and very infrequent metastatic spread. The tumour is also recognised in oral and anogenital sites. Cutaneous lesions present most commonly on the sole of the foot. We report a unique case occurring in the female breast. [O] . Munro, N A, Smith, C, Purushotham, A D 1999

机译：女性乳房疣状癌：疣状癌是一种罕见的鳞状细胞来源的皮肤恶性肿瘤。其特征在于可忽略的细胞异型性和低有丝分裂率。这些反映在缓慢的局部侵入行为和非常罕见的转移扩散中。肿瘤也在口腔和肛门生殖器部位被识别。皮肤损伤最常见于足底。我们报告了一个发生在女性乳房的独特病例。
10. Lung Squamous Cell Carcinoma Stem Cells as Immunotherapy Targets. [R] . Kim, C. 2017

机译：肺鳞状细胞癌干细胞作为免疫治疗靶点。

Cancer-associated fibroblasts are an infrequent finding in the microenvironment of proliferative verrucous leukoplakia-associated squamous cell carcinoma

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