PET-CT in MM: a new definition of CR.

摘要

Importantly, multivariate analysis revealed that patients with persistence of 18F-fluorodeoxyglucose (FDG) uptake 3, months after ASCT had significantly worse progression-free survival (PFS) and overall survival (OS). The prognostic impact of this parameter was stronger than that of cytogenetic abnormalities. These data strengthen those already reported by the group from Little Rock that showed that complete FDG suppression after induction (before transplantation) conferred superior OS and event-free survival, regardless of gene array-defined risk, in the context of total therapy 3. In both studies, the presence of more than 3 FDG-avid focal lesions at baseline was an independent parameter associated with inferior PFS.