Single-armphase II trial to evaluate efficacy and tolerance of regorafenib monotherapy in patients over 70 with previously treated metastatic colorectal adenocarcinoma FFCD 1404-REGOLD

Aparicio Thomas; Darut-Jouve Ariane; Akouz Faiza Khemissa; Monterymard Carole; Artru Pascal; Cany Laurent; Romano Olivier; Valenza Bruno; Le Foll Christine; Delbaldo Catherine; Falandry Claire; Monnereau Emmanuelle Norguet; Ben Abdelghani Meher; Smith Denis; Rinaldi Yves; Verge Denis Pere; Baize Nathalie; Maillard Emmanuel; Dohan Anthony; Des Guetz Gaetan; Pamoukdjian Frederic; Lepage Come

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Single-armphase II trial to evaluate efficacy and tolerance of regorafenib monotherapy in patients over 70 with previously treated metastatic colorectal adenocarcinoma FFCD 1404-REGOLD

机译：用先前治疗的转移结直肠腺癌FFCD 1404-regold评估70多种患者患者患者的疗效和耐受性

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Background: Regorafenib significantly increases overall survival (OS) in patients with metastatic colorectal cancer previously treated but gives toxicities.

机译：背景：雷戈拉非尼显著提高了转移性结直肠癌患者的总生存率（OS），这些患者之前接受过治疗，但有毒性。

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来源
《Journal of geriatric oncology》 |2020年第8期|共8页
作者
Aparicio Thomas; Darut-Jouve Ariane; Akouz Faiza Khemissa; Monterymard Carole; Artru Pascal; Cany Laurent; Romano Olivier; Valenza Bruno; Le Foll Christine; Delbaldo Catherine; Falandry Claire; Monnereau Emmanuelle Norguet; Ben Abdelghani Meher; Smith Denis; Rinaldi Yves; Verge Denis Pere; Baize Nathalie; Maillard Emmanuel; Dohan Anthony; Des Guetz Gaetan; Pamoukdjian Frederic; Lepage Come;
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作者单位

Univ Paris Gastroenterol &

Digest Oncol Dept CHU St Louis AP HP Paris France;

Inst Cancerol Bourgogne Oncol Dept Dijon France;

CH Perpignan Hepatol Gastroenterol Dept Hop St Jean Perpignan France;

Federat Francophone Cancerol Digest Biostat Dept Dijon France;

Hop Jean Mermoz Oncol Dept Lyon France;

Polyclin Francheville Radiotherapy &

Oncol Dept Perigueux France;

Inst Cancerol Lille Metropole Oncol Dept Villeneuve Dascq France;

CHI Frejus St Raphael Oncol Dept Frejus France;

Grand Hop Est Francilien Oncol Dept Site Marne Vallee Jossigny France;

Hop Diaconesses Croix St Simon Oncol Dept Paris France;

CH Lyon Sud Oncol Dept Pierre Benite France;

CHU La Timone Hepatogastroenterol &

Med Oncol Dept Marseille France;

Ctr Paul Strauss Oncol Dept Strasbourg France;

CHU Bordeaux Digest Oncol Dept Bordeaux France;

Hop Europeen Marseille Hepatogastroenterol Dept Marseille France;

Hop St Joseph St Luc Hepatogastroenterol Dept Lyon France;

CHU Angers Oncol Dept Hotel Dieu Angers France;

CH Annecy Genevois Hepatogastroenterol Dept Pringy France;

CHU Cochin AP HP Radiol Dept Paris France;

CHU Dupuytren Oncol Dept Limoges France;

CHU Avicenne AP HP Geriatr Dept Bobigny France;

Univ Hosp Dijon Gastroenterol &

Digest Oncol Dept Dijon France;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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2. Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer: a randomized phase Ⅲ ARTIST trial [J] . Zhong-Zhen Guan, Dong Wang, Shu-Kui Qin, 癌症（英文版） . 2011,第010期
3. Efficacy of third-line pemetrexed monotherapy versus pemetrexed combination with bevacizumab in patients with advanced EGFR mutation-positive lung adenocarcinoma [J] . Cheng-Zhi Zhou, Yin-Yin Qin, Zhan-Hong Xie, 中国癌症研究（英文版） . 2014,第006期
4. Study protocol of the Asian XELIRIrnProjecT (AXEPT): a multinational, randomized,rnnon‑inferiority, phase III trial of second‑linernchemotherapy for metastatic colorectal cancer,rncomparing the efficacy and safety of XELIRIrnwith or without bevacizumab versus FOLFIRIrnwith or without bevacizumab [J] . Masahito Kotaka, Hiroshi Matsumoto, Kentaro Yamazaki, 癌症（英文版） . 2016,第012期
5. Single-armphase II trial to evaluate efficacy and tolerance of regorafenib monotherapy in patients over 70 with previously treated metastatic colorectal adenocarcinoma FFCD 1404-REGOLD [J] . Aparicio Thomas, Darut-Jouve Ariane, Akouz Faiza Khemissa, Journal of geriatric oncology . 2020,第3期

机译：用先前治疗的转移结直肠腺癌FFCD 1404-regold评估70多种患者患者患者的疗效和耐受性
6. A higher ctDNA fraction decreases survival in regorafenib-treated metastatic colorectal cancer patients. Results from the regorafenib's liquid biopsy translational biomarker phase II pilot study [J] . Matthias Unseld, Jelena Belic, Kerstin Pierer, International Journal of Cancer =: Journal International du Cancer . 2021,第6期

机译：较高的CTDNA分数降低了可释放的转移性结肠直肠癌患者的存活。 Regorafenib液检结果翻译生物标志物II期试点研究的结果
7. A Phase II Study of Regorafenib With a Lower Starting Dose in Patients With Metastatic Colorectal Cancer: Exposure-Toxicity Analysis of Unbound Regorafenib and Its Active Metabolites (RESET Trial) [J] . Clinical colorectal cancer . 2020,第1期

机译：重转移结直肠癌患者较低的起始剂量的II期研究：未结合的令人骨折和活性代谢物的毒性分析及其活性代谢物（复位试验）
8. Correlation between development of hypertension and efficacy in metastatic colorectal cancer patients treated with bevacizumab [C] . Horinouchi Y., Sakurada T., Nakamura T., European Association for Clinical Pharmacology and Therapeutics . 2011

机译：北伐单抗治疗转移性结直肠癌患者高血压与疗效的相关性
9. A Modeling-Based Evaluation of the Evidential Basis for and Cost Effectiveness of Intensive Post-Diagnosis Extra-Colonic Surveillance of Non-Metastatic Colorectal Cancer Patients [D] . Popp, Jonah. 2018

机译：非转移性结直肠癌患者强化诊断后大肠结肠镜检查的证据基础和成本效益的基于模型的评估
10. Efficacy and safety of trifluridine/tipiracil plus bevacizumab and trifluridine/tipiracil or regorafenib monotherapy for chemorefractory metastatic colorectal cancer: a retrospective study [O] . Keigo Chida, Daisuke Kotani, Yoshiaki Nakamura, 2021

机译：Trifluridine / Tipiracil Plus Bevacizumab和Trifluridine / Tipiracil或RegorafeNib单药治疗的疗效和安全性用于切化用法转移结直肠癌：回顾性研究
11. Analysis of tumor location: A retrospective trial for evaluating the safety and efficacy of regorafenib for patients with metastatic colorectal cancer: HGCSG1401 [O] . T. Miyagishima, S. Yuki, T. Muranaka, 2017

机译：肿瘤地点分析：回顾性试验，用于评估术患者转移结直肠癌患者的术语：HGCSG1401
12. Phase I/II Trial of Epothilone Analog BMS-247550, Mitoxantrone, and Prednisone in HRPC Patients Previously Treated with Chemotherapy [R] . Rosenberg, J. E. 2006

机译：埃博霉素类似物Bms-247550，米托蒽醌和泼尼松用于化疗前HRpC患者的I / II期试验

Single-armphase II trial to evaluate efficacy and tolerance of regorafenib monotherapy in patients over 70 with previously treated metastatic colorectal adenocarcinoma FFCD 1404-REGOLD

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