Engineering Yarrowia lipolytica for de novo production of tetraacetyl phytosphingosine

Han Changpyo; Jang Minjeong; Kim Min Ju; Han Man-Ho; Lee Kyeong-Ryoon; Hahn Ji-Sook; Ahn Jungoh

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Engineering Yarrowia lipolytica for de novo production of tetraacetyl phytosphingosine

机译：工程Yarrowia Lipolytica用于De Novo生产四乙酰植物磷酸盐

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Aims To genetically engineer the oleaginous yeast Yarrowia lipolytica for de novo production of tetraacetylphytosphingosine (TAPS), a precursor of phytosphingosine, and optimization of fermentation conditions for high yield.

机译：目的对产油酵母Yarrowia lipolytica进行基因工程，以从头生产植物鞘氨醇的前体四乙酰基植物鞘氨醇（TAPS），并优化发酵条件以获得高产。

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来源
《Journal of applied microbiology》 |2021年第6期|共12页
作者
Han Changpyo; Jang Minjeong; Kim Min Ju; Han Man-Ho; Lee Kyeong-Ryoon; Hahn Ji-Sook; Ahn Jungoh;
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作者单位

Korea Res Inst Biosci &

Biotechnol Biotechnol Proc Engn Ctr 30 Yeongudanji Ro Cheongju 28116 Chungcheongbuk South Korea;

Korea Res Inst Biosci &

Biotechnol Biotechnol Proc Engn Ctr 30 Yeongudanji Ro Cheongju 28116 Chungcheongbuk South Korea;

Korea Res Inst Biosci &

Biotechnol Lab Anim Resource Ctr Cheongju South Korea;

Korea Res Inst Biosci &

Biotechnol Biotechnol Proc Engn Ctr 30 Yeongudanji Ro Cheongju 28116 Chungcheongbuk South Korea;

Korea Res Inst Biosci &

Biotechnol Lab Anim Resource Ctr Cheongju South Korea;

Seoul Natl Univ Inst Chem Proc Interdisciplinary Program Bioengn Seoul South Korea;

Korea Res Inst Biosci &

Biotechnol Biotechnol Proc Engn Ctr 30 Yeongudanji Ro Cheongju 28116 Chungcheongbuk South Korea;

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原文格式 PDF
正文语种 eng
中图分类应用微生物学;
关键词
ATF2; ceramides; optimization; SLI1; sphingolipid; tetraacetyl phytosphingosine; tetraacetylphytosphingosine; Yarrowia lipolytica;

机译：ATF2;神经酰胺;优化;SLI1;鞘脂;四乙酰肺磷酸盐;四乙酰苯齐磷苷;Yarrowia Lipolytica;

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2. De novo production of resveratrol from glycerol by engineering different metabolic pathways in Yarrowia lipolytica [J] . Qin He, Patrycja Szczepańska, Tigran Yuzbashev, Metabolic Engineering Communications . 2020,第2期

机译：通过工程不同代谢途径从甘油中从甘油中获得的Novo生产在Yarrowia Lipolytica中
3. Combinatorial Engineering of Yarrowia lipolytica as a Promising Cell Biorefinery Platform for the de novo Production of Multi-Purpose Long Chain Dicarboxylic Acids [J] . Ali Abghari, Catherine Madzak, Shulin Chen Fermentation . 2017,第3期

机译：解脂耶氏酵母作为有希望的细胞生物精制平台的组合工程，用于从头生产多用途长链二元羧酸
4. De novo Biosynthesis of Odd-Chain Fatty Acids in Yarrowia lipolytica Enabled by Modular Pathway Engineering [J] . Park Young-kyoung, Ledesma-Amaro Rodrigo, Nicaud Jean-Marc Frontiers in Bioengineering and Biotechnology . 2020,第1期

机译：由模块化途径工程实现Yarrawia Lipolytica的奇数链脂肪酸的德诺诺生物合成
5. Combinatorial Engineering Yarrowia Lipolytica As a Platform for Production of Long Chain ω - Hydroxy Fatty Acids from Renewable Feedstock(PPT) [C] . Ali Abghari, Shulin Chen AIChE Annual Meeting . 2016

机译：组合工程Yarrowia Lipolytica作为生产长链ω - 羟基脂肪酸的平台，来自可再生原料（PPT）
6. Engineering of Robust Enzymes and Their Production in the Non-Conventional Oleaginous Yeast Yarrowia lipolytica [D] . Wang, Weigao. 2021

机译：鲁棒酶的工程及其生产在非常规的含油酵母Yarrowia Lipolytica中
7. De novo production of resveratrol from glycerol by engineering different metabolic pathways in Yarrowia lipolytica [O] . Qin He, Patrycja Szczepańska, Tigran Yuzbashev, 2020

机译：通过工程不同代谢途径从甘油中从甘油中获得的Novo生产在Yarrowia Lipolytica中
8. De novo production of resveratrol from glycerol by engineering different metabolic pathways in Yarrowia lipolytica [O] . Qin He, Patrycja Szczepańska, Tigran Yuzbashev, 2020

机译：通过工程不同代谢途径从甘油中从甘油中获得的Novo生产在Yarrowia Lipolytica中
9. Expedited Access for Premarket Approval and De Novo Medical Devices Intended for Unmet MedicalNeed for Life Threatening or Irreversibly Debilitating Diseases or Conditions: Guidance for Industry and Food and Drug Administration Staff. [R] . 2015

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Engineering Yarrowia lipolytica for de novo production of tetraacetyl phytosphingosine

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