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首页> 外文期刊>Journal of Crohn’s & colitis >Concerns and Side Effects of Azathioprine During Adalimumab Induction and Maintenance Therapy for Japanese Patients With Crohn's Disease: A Subanalysis of a Prospective Randomised Clinical Trial [DIAMOND Study]
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Concerns and Side Effects of Azathioprine During Adalimumab Induction and Maintenance Therapy for Japanese Patients With Crohn's Disease: A Subanalysis of a Prospective Randomised Clinical Trial [DIAMOND Study]

机译:Azathioprine在日本乳酸疾病患者诱导和维持治疗期间的顾虑和副作用:治疗前瞻性随机临床试验的细胞分析[钻石研究]

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摘要

Background: Combining a thiopurine with the human anti-tumour necrosis factor-a monoclonal antibody adalimumab for Crohn's disease [CD] treatment is controversial with regard to efficacy and safety. By conducting a subanalysis of a multicentre, randomised, prospective, open-label trial [the DIAMOND study, UMIN registration number 000005146], we studied the risk of discontinuation of thiopurine in combination with adalimumab.
机译:背景:硫嘌呤与人抗肿瘤坏死因子a单克隆抗体阿达木单抗联合治疗克罗恩病[CD]在疗效和安全性方面存在争议。通过对一项多中心、随机、前瞻性、开放标签试验进行亚分析[DIAMOND研究,UMIN注册号000005146],我们研究了硫嘌呤联合阿达木单抗停药的风险。

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