Intestinal CD14(+) Macrophages Protect CD4(+)T Cells From Activation-induced Cell Death via Exosomal Membrane TNF in Crohn's Disease

摘要

Background and aims: Sustained activation of CD4(+)T cells plays important roles in the pathogenesis of Crohn's disease [CD]. Under physiologic conditions, activated T cells can be timely eliminated by a process termed activation-induced cell death [AICD], restraining T cell over-activation and preventing immunological destruction. We inquired whether defective AICD might explain CD4(+)T cell over-activation in CD and investigated the underlying mechanisms.