SYNTHESIS,PHOTOCHEMICAL PROPERTIES,AND CYTOTOXICITY OF 10-ALKYLPHENAZIN-2(10H)-ONES

摘要

In the present study,the synthesis of a variety of 10-alkylphenazin-2(10H)-ones by oxidative coupling between N-alkylbenzene-l,2-diamine and 1,2,4-benzenetriol under an oxygen atmosphere was realized,and their photochemical and biological properties were investigated.10-Methylphenazin-2(10H)-one,a reddish orange pigment,exhibited fluorescence in the visible light region upon exposure to ultraviolet light.Interestingly,the fluorescence from 10-methylphenazin-2(10H)-one consisted of two components.In addition,the cytotoxic evaluation of various synthetic compounds was performed.Among the compounds tested in this study,10-methylphenazin-2(10H)-one exhibited the most selective cytotoxic activity against human cancer A549 cells compared to normal MRC-5 cells.