Investigating the partial volume effects in magnetic resonance spectroscopy localization using high-resolution 3D MRI and segmentation

摘要

Introduction: Previous studies have proposed the methods that can decompose the mouse brain MRI scans into various anatomical regions. By performing proper registration of the high-resolution MRI to a brain atlas, an advanced tissue compartmentalization can be achieved, instead a simple decomposition into white matter, gray matter, and cerebrospinal fluids (CSF). The aim of this study was to investigate partial volume effects on proton magnetic resonance spectroscopy (1H MRS) voxels in the mouse brain, using high-resolution 3D MRI and segmentation.