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首页> 外文期刊>Annals of Clinical and Laboratory Science: Official Journal of the Association of Clinical Scientists >Case report: acute promyelocytic leukemia with +der(17)t(15;17) detected by fluorescence in situ hybridization (FISH).
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Case report: acute promyelocytic leukemia with +der(17)t(15;17) detected by fluorescence in situ hybridization (FISH).

机译:病例报告:通过荧光原位杂交(FISH)检测到+ der(17)t(15; 17)的急性早幼粒细胞白血病。

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摘要

We describe an unusual case of acute promyelocytic leukemia with +der(17)t(15;17) as the additional cytogenetic abnormality and with t(15;17) defined by fluorescence in situ hybridization (FISH) using a PML/RARA dual color, dual fusion translocation probe. By performing a step-by-step, complementary approach to evaluate unusual chromosomal abnormalities, we detected RARA/PML fusion on a marker chromosome similar to chromosome 17.
机译:我们将+ der(17)t(15; 17)作为另外的细胞遗传学异常,并通过使用PML / RARA双色荧光原位杂交(FISH)定义的t(15; 17),描述了一种罕见的急性早幼粒细胞白血病病例,双重融合易位探针。通过分步执行补充方法来评估异常染色体异常,我们在与17号染色​​体相似的标记染色体上检测到RARA / PML融合。

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