Circulating microRNA-1290 as a novel diagnostic and prognostic biomarker in human colorectal cancer

摘要

Our comprehensive miRNA microarray analyses identify the serum miRNA expression profiles differed significantly between controls and adenoma or CRC. Especially, miR-1290 expression is most statistically up-regulated in serum samples from adenoma or CRC patients versus controls, and is a promising, serum-based non-invasive biomarker for the detection and prognosis of colorectal neoplasia.Circulating microRNAs (miRNAs) are attracting major interest as potential non-invasive biomarkers for colorectal cancer (CRC). This study aimed to identify a novel serum miRNA biomarker for the early detection and/or evaluating prognosis of CRC patients.