Polygenic risk score-analysis of thromboembolism in patients with acute lymphoblastic leukemia

Jarvis Kirsten Brunsvig; Nielsen Rikke Linnemann; Gupta Ramneek; Hede Freja Dahl; Huttunen Pasi; Jonsson Olafur Gisli; Rank Cecilie Utke; Ranta Susanna; Saks Kadri; Trakymiene Sonata Saulyte; Tuckuviene Ruta; Tulstrup Morten; Ruud Ellen; Schmiegelow Kjeld; LeBlanc Marissa

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Polygenic risk score-analysis of thromboembolism in patients with acute lymphoblastic leukemia

机译：急性淋巴细胞白血病患者血栓栓塞的多基因风险分数分析

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Introduction: Thromboembolism (TE) is a common and serious toxicity of acute lymphoblastic leukemia (ALL) treatment, but studies of genetic predisposition have been underpowered with conflicting results. We tested whether TE in ALL and TE in the general adult population have a shared genetic etiology.

机译：导言：血栓栓塞（TE）是急性淋巴细胞白血病（ALL）治疗中常见且严重的毒性反应，但对遗传易感性的研究进展不足，结果相互矛盾。我们测试了ALL中的TE和普通成年人群中的TE是否有共同的遗传病因。

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来源
《Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis》 |2020年第1期|共6页
作者
Jarvis Kirsten Brunsvig; Nielsen Rikke Linnemann; Gupta Ramneek; Hede Freja Dahl; Huttunen Pasi; Jonsson Olafur Gisli; Rank Cecilie Utke; Ranta Susanna; Saks Kadri; Trakymiene Sonata Saulyte; Tuckuviene Ruta; Tulstrup Morten; Ruud Ellen; Schmiegelow Kjeld; LeBlanc Marissa;
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作者单位

Oslo Univ Hosp Dept Pediat Hematol &

Oncol Postboks 4950 N-0424 Oslo Norway;

Tech Univ Denmark Dept Hlth Technol DK-2800 Lyngby Denmark;

Tech Univ Denmark Dept Hlth Technol DK-2800 Lyngby Denmark;

Tech Univ Denmark Dept Hlth Technol DK-2800 Lyngby Denmark;

Helsinki Univ Hosp New Childrens Hosp Dept Pediat Hematol Oncol &

Stem Cell Transplanta;

Landspitali Univ Hosp Childrens Hosp Barnaspitali Hringsins Hringbraut 101 IS-101 Reykjavik;

Univ Copenhagen Rigshosp Dept Hematol Belgdamsvej 9 DK-2100 Copenhagen Denmark;

Karolinska Univ Hosp Astrid Lindgren Childrens Hosp Eugeniavagen 3 S-17176 Solna Sweden;

Tallinn Childrens Hosp Dept Hematol &

Oncol EE-13419 Tallinn Estonia;

Vilnius Univ Fac Med Clin Childrens Dis LT-08410 Vilnius Lithuania;

Aalborg Univ Hosp Dept Pediat Hobrovej 18-22 DK-9100 Aalborg Denmark;

Univ Hosp Copenhagen Rigshosp Dept Pediat &

Adolescent Med Blegdamsvej 9 DK-92100 Copenhagen;

Oslo Univ Hosp Dept Pediat Hematol &

Oncol Postboks 4950 N-0424 Oslo Norway;

Univ Hosp Copenhagen Rigshosp Dept Pediat &

Adolescent Med Blegdamsvej 9 DK-92100 Copenhagen;

Oslo Univ Hosp Oslo Ctr Biostat &

Epidemiol Postboks 4950 N-0424 Oslo Norway;

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正文语种 eng
中图分类神经病学;
关键词
Acute lymphoblastic leukemia; Thromboembolism; Polygenic risk score;

机译：急性淋巴细胞白血病;血栓栓塞;多基因风险分数;

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Polygenic risk score-analysis of thromboembolism in patients with acute lymphoblastic leukemia

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