Levels of the cancer biomarker CA 19-9 are associated with thrombin generation in plasma from treatment-na?ve pancreatic cancer patients

摘要

Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with a hypercoagulable state and high mortality. Increases in the plasma levels of tumor marker carbohydrate antigen (CA) 19-9 are used in diagnosis and follow-up but have also been reported to precede venous thromboembolism (VTE).