Identification of high-grade serous ovarian cancer miRNA species associated with survival and drug response in patients receiving neoadjuvant chemotherapy: a retrospective longitudinal analysis using matched tumor biopsies

摘要

Longitudinal analysis of high-grade serous-epithelial ovarian cancer-matched biopsies identified miR-199a-3p, miR-199a-5p, miR-181a-5p and let-7g-5p as independently associated to patients' prognosis. Combined analysis of P-Smad2 and miR-181a-5p carried out better than each biomarker alone in stratifying patients' risk of relapse and allowed to initially select those patients who could be treated with different therapies.Neoadjuvant chemotherapy (NACT) has been recognized as a reliable therapeutic strategy in patients with unresectable advanced epithelial ovarian cancer (EOC). The molecular events leading to platinum (Pt) response in NACT settings have hitherto not been explored. In the present work, longitudinal changes of miRNA expression profile were investigated to identify miRNA families with prognostic role in high-grade serous EOC patients who received the NACT regimen.