Surgery for malignant pleural mesothelioma after radiotherapy (SMART): final results from a single-centre, phase 2 trial

Cho B. C. John; Donahoe Laura; Bradbury Penelope A.; Leighl Natasha; Keshavjee Shaf; Hope Andrew; Pal Prodipto; Cabanero Michael; Czarnecka Kasia; McRae Karen; Tsao Ming-Sound; Perrot Marc de

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Surgery for malignant pleural mesothelioma after radiotherapy (SMART): final results from a single-centre, phase 2 trial

机译：放射治疗后恶性胸膜间皮瘤的手术（SMART）：单一中心，第2阶段试验的最终结果

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Background A novel approach for managing malignant pleural mesothelioma, surgery for mesothelioma after radiotherapy (SMART), consisting of a short accelerated course of high-dose, hemithoracic, intensity modulated radiotherapy (IMRT) followed by extrapleural pneumonectomy was developed. The aim of this study was to evaluate the clinical feasibility of the SMART protocol.

机译：背景：一种治疗恶性胸膜间皮瘤的新方法，即放疗后间皮瘤手术（SMART），包括短期加速高剂量、半胸、调强放疗（IMRT），然后胸膜外全肺切除术。本研究的目的是评估SMART方案的临床可行性。

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《The lancet oncology》 |2021年第2期|共8页
作者
Cho B. C. John; Donahoe Laura; Bradbury Penelope A.; Leighl Natasha; Keshavjee Shaf; Hope Andrew; Pal Prodipto; Cabanero Michael; Czarnecka Kasia; McRae Karen; Tsao Ming-Sound; Perrot Marc de;
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作者单位

Univ Toronto Univ Hlth Network Dept Radiat Oncol Toronto ON Canada;

Univ Toronto Univ Hlth Network Toronto Gen Hosp Princess Margaret Canc Ctr Div Thorac Surg;

Univ Toronto Univ Hlth Network Div Med Oncol Toronto ON Canada;

Univ Toronto Univ Hlth Network Div Med Oncol Toronto ON Canada;

Univ Toronto Univ Hlth Network Toronto Gen Hosp Princess Margaret Canc Ctr Div Thorac Surg;

Univ Toronto Univ Hlth Network Dept Radiat Oncol Toronto ON Canada;

Univ Toronto Univ Hlth Network Dept Pathol Lab Med Program Toronto ON Canada;

Univ Toronto Univ Hlth Network Toronto Gen Hosp Princess Margaret Canc Ctr Div Thorac Surg;

Univ Toronto Univ Hlth Network Dept Anesthesia &

Pain Management Toronto ON Canada;

Univ Toronto Univ Hlth Network Dept Pathol Lab Med Program Toronto ON Canada;

Univ Toronto Univ Hlth Network Toronto Gen Hosp Princess Margaret Canc Ctr Div Thorac Surg;

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正文语种 eng
中图分类肿瘤学;
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专利

1. Results of flexible 3D-conformal radiotherapy for patients with diffuse malignant pleural mesothelioma and comparative study of this technique with conventional radiotherapy [J] . Fengwei Wang, Siwei Zhu, Xinzhuo Wang, 中德临床肿瘤学杂志：英文版 . 2008,第005期
2. Complex Target Volume Delineation and Treatment Planning in Radiotherapy for Malignant Pleural Mesothelioma (MPM) [J] . Aaron Innocent Bogmis, Adrian Raducu Popa, Daniela Adam, 医学物理学、临床工程、放射肿瘤学（英文） . 2020,第003期
3. Intrathoracic latissimus dorsi muscle transposition: a reliable technique for prevention of bronchopleural fistula developing after extrapleural pneumonectomy and external beam radiotherapy in malignant pleural mesothelioma [J] . Maged M. Elshafiey, Hisham A. El-hossieny, Ismail A. Mourad 中德临床肿瘤学杂志（英文版） . 2012,第007期
4. Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART): a multicentre, open-label, phase 3, randomised controlled trial [J] . Clive Amelia O., Taylor Hazel, Dobson Lee, The lancet oncology . 2016,第8期

机译：预防性放射疗法预防恶性胸膜间皮瘤（SMART）外科手术和大口径胸膜手术后的程序转移：一项多中心，开放标签，3期随机对照试验
5. Surgical and large bore pleural interventions in malignant pleural mesothelioma and radiotherapy trial (The SMART Trial) [J] . Clive A. O. Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2013,第Suppla1期

机译：恶性胸膜间皮瘤的外科和大口径胸膜介入治疗及放射治疗试验（SMART试验）
6. Protocol for the surgical and large bore procedures in malignant pleural mesothelioma and radiotherapy trial (SMART Trial): an RCT evaluating whether prophylactic radiotherapy reduces the incidence of procedure tract metastases [J] . Amelia O Clive, Anna J Morley, Emma de Winton, BMJ Open . 2015,第1期

机译：恶性胸膜间皮瘤和放射治疗试验中的外科手术和大口径手术规程（SMART试验）：一项RCT评估预防性放疗是否可降低手术部位转移的发生率
7. Feasibility trial assessing intrapleural photodynamic therapy combined with pleurectomy/decortication then chemotherapy in malignant pleural mesothelioma patients. [C] . Serge Mordon, Camille Munck, Ecaterina Surmei-Pintilie, International Photodynamic Association World Congress . 2019

机译：可行性试验评估腹膜内光动力学治疗与胸膜切除术/凝固患者患者在恶性胸膜间皮瘤患者中相结合。
8. Functional, Volumetric, and Textural Analysis of Malignant Pleural Mesothelioma Using Computed Tomography and Deep Convolutional Neural Networks [D] . Guemundsson, Eyjólfur. 2019

机译：利用计算机断层扫描和深卷积神经网络的恶性胸腔间皮瘤的功能性，体积和纹理分析
9. Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART): a multicentre open-label phase 3 randomised controlled trial [O] . Amelia O Clive, Hazel Taylor, Lee Dobson, -1

机译：预防性放射疗法预防恶性胸膜间皮瘤（SMART）外科手术和大口径胸膜手术后的程序转移：一项多中心开放标签3期随机对照试验
10. Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART): a multicentre, open-label, phase 3, randomised controlled trial. [O] . Clive, AO, Taylor, H, Dobson, L, 2016

机译：预防性放射疗法可预防恶性胸膜间皮瘤（SMART）的外科手术和大口径胸膜手术后的程序转移：一项多中心，开放标签，3期随机对照试验。
11. Randomized Phase II Trial of Adjuvant WT-1 Analog Peptide Vaccine in Patients with Malignant Pleural Mesothelioma after Completion of Multimodality Therapy. [R] . Zauderer, M. G. 2017

机译：多模态治疗完成后恶性胸膜间皮瘤患者辅助WT-1类似物肽疫苗的随机II期临床试验。

Surgery for malignant pleural mesothelioma after radiotherapy (SMART): final results from a single-centre, phase 2 trial

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