U-Shaped Relationship of Leukocyte Telomere Length With All-Cause and Cancer-Related Mortality in Older Men

Yeap Bu B.; Hui Jennie; Knuiman Matthew W.; Flicker Leon; Divitini Mark L.; Arscott Gillian M.; Twigg Stephen M.; Almeida Osvaldo P.; Hankey Graeme J.; Golledge Jonathan; Norman Paul E.; Beilby John P.

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U-Shaped Relationship of Leukocyte Telomere Length With All-Cause and Cancer-Related Mortality in Older Men

机译：白细胞端粒长度与老年人全源和癌症相关死亡的U形关系

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Background: Telomeres are essential DNA-protein complexes whose attrition results in cellular dysfunction and senescence. Leukocyte telomere length (LTL) correlates with tissue telomere length, representing a biomarker for biological age. However, its predictive value for mortality risk, and for cardiovascular versus cancer deaths, in older adults remains uncertain.

机译：背景：端粒是重要的DNA-蛋白质复合物，其磨损导致细胞功能障碍和衰老。白细胞端粒长度（LTL）与组织端粒长度相关，代表生物年龄的生物标志物。然而，其对老年人死亡风险以及心血管疾病与癌症死亡的预测价值仍不确定。

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《The journals of gerontology.Series A. Biological sciences and medical sciences》 |2021年第1期|共8页
作者
Yeap Bu B.; Hui Jennie; Knuiman Matthew W.; Flicker Leon; Divitini Mark L.; Arscott Gillian M.; Twigg Stephen M.; Almeida Osvaldo P.; Hankey Graeme J.; Golledge Jonathan; Norman Paul E.; Beilby John P.;
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作者单位

Univ Western Australia Med Sch Perth WA Australia;

Sir Charles Gairdner Hosp PathWest Lab Med Perth WA Australia;

Univ Western Australia Sch Populat &

Global Hlth Perth WA Australia;

Univ Western Australia Med Sch Perth WA Australia;

Univ Western Australia Sch Populat &

Global Hlth Perth WA Australia;

Sir Charles Gairdner Hosp PathWest Lab Med Perth WA Australia;

Univ Sydney Sydney Med Sch Dept Endocrinol Sydney NSW Australia;

Univ Western Australia Med Sch Perth WA Australia;

Univ Western Australia Med Sch Perth WA Australia;

James Cook Univ Queensland Res Ctr Peripheral Vasc Dis Townsville Qld Australia;

Univ Western Australia Med Sch Perth WA Australia;

Sir Charles Gairdner Hosp PathWest Lab Med Perth WA Australia;

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原文格式 PDF
正文语种 eng
中图分类老年病学;
关键词
Cancer; Cardiovascular disease; Leukocyte telomere length; Male ageing; Mortality;

机译：癌症;心血管疾病;白细胞端粒长度;男性老化;死亡率;

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2. Association of leukocyte telomere length with non-alcoholic fatty liver disease in patients with type 2 diabetes [J] . Min Zhang, Man-Li Hu, Jiao-Jiao Huang, 中华医学杂志（英文版） . 2019,第024期
3. The relationships between step count and all-cause mortality and cardiovascular events:A dose-response meta-analysis [J] . Mingxin Sheng, Bowen Zhang, Yiting Liu, 运动与健康科学（英文版） . 2021,第006期
4. Leukocyte telomere length and epigenetic-based mortality risk score: associations with all-cause mortality among older adults [J] . Gao Xu, Zhang Yan, Mons Ute, Epigenetics: official journal of the DNA Methylation Society . 2018,第8期

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5. Leukocyte telomere length, cancer incidence and all-cause mortality among Chinese adults: Singapore Chinese Health Study [J] . Hamed Samavat, Hung N. Luu, Kenneth B. Beckman, International Journal of Cancer =: Journal International du Cancer . 2021,第2期

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6. Leukocyte Telomere Length and All-Cause Mortality: A Between-Within Twin Study With Time-Dependent Effects Using Generalized Survival Models [J] . Zhan Yiqiang, Liu Xing-Rong, Reynolds Chandra A., American Journal of Epidemiology . 2018,第10期

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8. A Bayesian approach to Meta-Regression: The relationship between Body Mass Index and all-cause mortality. [D] . Marker, Mahtab. 2007

机译：贝叶斯方法进行元回归：体重指数与全因死亡率之间的关系。
9. Leukocyte telomere length and epigenetic-based mortality risk score: associations with all-cause mortality among older adults [O] . Xu Gao, Yan Zhang, Ute Mons, 2018

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11. Clinical Associations of Leukocyte Telomere Length in a Cohort of Repatriated Prisoners of War [R] . Pavelites, J J, Linnville, SE, Moore, J L 2014

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U-Shaped Relationship of Leukocyte Telomere Length With All-Cause and Cancer-Related Mortality in Older Men

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