Control of carcinoid syndrome with everolimus.

摘要

In February 2004, a 50-year-old woman was diagnosed with well-differentiated neuroendocrine carcinoma of the ileum with multiple bilobar hepatic metastases that occupied nearly all the parenchyma. An immunohistochemical analysis was positive for chromogranin A, synaptophysin and Ki67 level of 2%.In July 2004, the patient underwent treatment with octreotide LAR 30 mg/28 days. This resulted in a disappearance of the diarrhea and flushing and decrease in urinary 5-HIAA levels (up to 85% of reduction). In September 2006, interferon-alpha2b was added to octreotide due to disease progression.