Multiscale systems biology: A special issue devoted to understanding biology and medicine across multiple scales

摘要

The central goal of Systems Biology is to understand and quantitatively predict biological phenomena at a global level, where biological functions result from complex mechanisms that occur across diverse scales, from the.atomic and molecular to the organelle and cellular level, and then extended to the tissue, organism, and population level. In bioengi-neering applications, unique challenges include: (1) the regulatory and kinetic complexity of gene and metabolic and signaling pathways, (2) generation or response to physical forces, and (3) complex transport physics.