Characteristics of pyrexia in BRAF(V600E/K) metastatic melanoma patients treated with combined dabrafenib and trametinib in a phase I/II clinical trial

Menzies A. M.; Ashworth M. T.; Swann S.; Kefford R. F.; Flaherty K.; Weber J.; Infante J. R.; Kim K. B.; Gonzalez R.; Hamid O.; Schuchter L.; Cebon J.; Sosman J. A.; Little S.; Sun P.; Aktan G.; Ouellet D.; Jin F.; Long G. V.; Daud A.

首页> 外文期刊>Annals of oncology: official journal of the European Society for Medical Oncology >Characteristics of pyrexia in BRAF(V600E/K) metastatic melanoma patients treated with combined dabrafenib and trametinib in a phase I/II clinical trial

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Characteristics of pyrexia in BRAF(V600E/K) metastatic melanoma patients treated with combined dabrafenib and trametinib in a phase I/II clinical trial

机译：在I / II期临床试验中，达拉非尼和曲美替尼联合治疗的BRAF（V600E / K）转移性黑色素瘤患者发热异常的特征

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Background: Pyrexia is a frequent adverse event with combined dabrafenib and trametinib therapy (CombiDT), but little is known of its clinical associations, etiology, or appropriate management.

机译：背景：发热是达拉非尼和曲美替尼联合治疗（CombiDT）的常见不良事件，但对其临床关联，病因或适当治疗知之甚少。

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《Annals of oncology: official journal of the European Society for Medical Oncology》 |2015年第2期|共7页
作者
Menzies A. M.; Ashworth M. T.; Swann S.; Kefford R. F.; Flaherty K.; Weber J.; Infante J. R.; Kim K. B.; Gonzalez R.; Hamid O.; Schuchter L.; Cebon J.; Sosman J. A.; Little S.; Sun P.; Aktan G.; Ouellet D.; Jin F.; Long G. V.; Daud A.;
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正文语种 eng
中图分类肿瘤学;
关键词
melanoma; BRAF; dabrafenib; trametinib; pyrexia; fever;

机译：黑色素瘤;BRAF;达布拉非尼;曲美替尼;发热;发烧;

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1. Characteristics of pyrexia in BRAF(V600E/K) metastatic melanoma patients treated with combined dabrafenib and trametinib in a phase I/II clinical trial [J] . Menzies A. M., Ashworth M. T., Swann S., Annals of oncology: official journal of the European Society for Medical Oncology . 2015,第2期

机译：在I / II期临床试验中，达拉非尼和曲美替尼联合治疗的BRAF（V600E / K）转移性黑色素瘤患者发热异常的特征
2. Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study [J] . Long G. V., Flaherty K. T., Stroyakovskiy D., Annals of oncology: official journal of the European Society for Medical Oncology . 2017,第7期

机译：Dabrafenib Plus Trametinib对Dabrafenib患者转移BRAF V600E / K-突变体黑素瘤的单一疗法：长期存活和安全分析3阶段研究
3. Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial [J] . Planchard David, Besse Benjamin, Groen Harry J. M., The lancet oncology . 2016,第7期

机译：达布拉非尼联合曲美替尼治疗先前治疗过的BRAF（V600E）-突变型转移性非小细胞肺癌患者：一项开放性，多中心，2期试验
4. Preliminary results of a phase I/II clinical trial using in situ photoimmunotherapy combined with imiquimod for metastatic melanoma patients [C] . Xiaosong Li, Mark F. Naylor, Robert E. Nordquist, . 2010

机译：使用原位光免疫疗法联合咪喹莫特治疗转移性黑色素瘤患者的I / II期临床试验的初步结果
5. Associating Computed Tomography (CT) Imaging Response Criteria and Texture Analysis Measurements with Survival in Patients with Metastatic Melanoma Treated with Anti-angiogenic Therapy. [D] . Gray, Mark Russell. 2014

机译：将计算机断层扫描（CT）成像反应标准和纹理分析测量值与接受抗血管生成治疗的转移性黑色素瘤患者的生存率相关联。
6. Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study [O] . G. V. Long, K. T. Flaherty, D. Stroyakovskiy, -1

机译：转移性BRAF V600E / K突变型黑色素瘤患者的达拉非尼联合曲美替尼与达拉非尼单药治疗：一项3期研究的长期生存和安全性分析
7. Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study [O] . G.V. Long, K.T. Flaherty, D. Stroyakovskiy, 2017

机译：Dabrafenib Plus Trametinib对Dabrafenib患者转移BRAF V600E / K-突变体黑素瘤的单一疗法：长期存活和第3期研究的安全分析

Characteristics of pyrexia in BRAF(V600E/K) metastatic melanoma patients treated with combined dabrafenib and trametinib in a phase I/II clinical trial

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