Vitamin D Supplementation: Not So Simple in Sarcoidosis

摘要

Introduction: Americans are increasingly receiving vitamin D supplementation, often based on low-measured 25-hydroxyvitamin D (25-OH-vit D). In sarcoidosis, there is often increased metabolism of 25-OH-vit D to 1,25-dihydroxy-vitamin D (1,25-OH-vit D), so 25-OH-vit D may remain low, despite high levels of 1,25-OH-vit D. In such cases, vitamin D supplementation may lead to hypercalcemia.