Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia

摘要

Aim A Japanese individual with schizophrenia harboring a novel exonic deletion in RELN was recently identified by genome-wide copy-number variation analysis. Thus, the present study aimed to generate and analyze a model mouse to clarify whether Reln deficiency is associated with the pathogenesis of schizophrenia.