Lipophilicity study of fifteen fluoroquinolones by reversed-phase thin-layer chromatography

摘要

The lipophilicity of fifteen fluoroquinolones has been investigated. Reversed-phase thin layer chromatography with densitometric detection was applied to determine the R-M0 factor. The RP-TLC investigations were performed in mixtures of organic modifier-water. The partition coefficients of examined fluoroquinolones were also calculated with computational programs. All the obtained data, from experimental methods and theoretical calculations, were compared and a suitable conclusion was reached. The received results demonstrate that the RP-TLC method may be the only reliable technique for fluoroquinolones in describing their lipophilic nature as well as the activity.