An Evolutionary Analysis of Low Molecular Mass Protein 7 (LMP7)

摘要

Processing of human intracellular proteins was carried out by a group of genes present in class I major histocompatibility complex (MHC). LMP7 played an important role in MHC class-Iantigen presentation pathway. Therefore, genetic variation of LMP gene may affect outcome of HBV infection. The evolutionary analysis of LMP7 protein was performed in different mammals using phlogeny.fr. The protein sequences of LMP7 were procured from UniProt public database and multiple sequence alignment was performedwith 'MUSCLE' with default parameter. Results of evolutionary analysis revealed divergent evolution of LMP7 gene consequently with species divergence. Bos taurus showed highest evolutionary relevance with Homo sapiens LMP7 among different species studied.